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Assay Detail

CHEMBL887934

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of 1,8-ANS from aFABP by fluorescence based-assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Fatty acid-binding protein, adipocyte (CHEMBL2083)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).
Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R, Harrity T, Stoffel R, Taylor DS, Lavoie TB, Kish K, Jacobson BL, Sheriff S, Adam LP, Ewing WR, Robl JA.
Bioorg Med Chem Lett (2007) 17 : 3511 -3515
PubMed 17502136 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 7.64 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL247298 1 8.70
CHEMBL245282 1 8.57
CHEMBL245653 1 8.47
CHEMBL247529 1 8.46
CHEMBL126078 1 8.22
CHEMBL248144 1 8.03
CHEMBL394966 1 7.92
CHEMBL248145 1 7.75
CHEMBL248120 1 7.55
CHEMBL246902 1 7.44
CHEMBL116533 1 7.24
CHEMBL245857 1 6.89
CHEMBL8659 OLEIC ACID 2.0 1 6.73
CHEMBL82293 PALMITIC ACID -1.0 1 6.47
CHEMBL394440 1 6.19
CHEMBL245284 1 -
CHEMBL396698 1 -
CHEMBL247920 1 -
CHEMBL246062 1 -
CHEMBL397385 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL247298 Ki = 2.0 nM 8.70
CHEMBL245282 Ki = 2.7 nM 8.57
CHEMBL245653 Ki = 3.4 nM 8.47
CHEMBL247529 Ki = 3.5 nM 8.46
CHEMBL126078 Ki = 6.0 nM 8.22
CHEMBL248144 Ki = 9.3 nM 8.03
CHEMBL394966 Ki = 12.0 nM 7.92
CHEMBL248145 Ki = 18.0 nM 7.75
CHEMBL248120 Ki = 28.0 nM 7.55
CHEMBL246902 Ki = 36.0 nM 7.44
CHEMBL116533 Ki = 58.0 nM 7.24
CHEMBL245857 Ki = 130.0 nM 6.89
CHEMBL8659 OLEIC ACID Ki = 185.0 nM 6.73
CHEMBL82293 PALMITIC ACID Ki = 336.0 nM 6.47
CHEMBL394440 Ki = 650.0 nM 6.19
CHEMBL245284 Ki < 2.0 nM -
CHEMBL396698 Ki < 2.0 nM -
CHEMBL247920 Ki < 2.0 nM -
CHEMBL246062 Ki > 2000.0 nM -
CHEMBL397385 Ki < 2.0 nM -