Assay Detail
Binding
CHEMBL887937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]2,3-bis[(2,4-dichlorobenzyl)oxy]benzoic acid from aFABP
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Fatty acid-binding protein, adipocyte (CHEMBL2083) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.48 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245284 | — | — | 1 | 8.48 |
| CHEMBL247920 | — | — | 1 | 8.13 |
| CHEMBL397385 | — | — | 1 | 8.06 |
| CHEMBL245653 | — | — | 1 | 7.89 |
| CHEMBL396698 | — | — | 1 | 7.89 |
| CHEMBL247529 | — | — | 1 | 7.50 |
| CHEMBL245282 | — | — | 1 | 7.32 |
| CHEMBL126078 | — | — | 1 | 7.02 |
| CHEMBL248145 | — | — | 1 | 6.52 |
| CHEMBL285527 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245284 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL247920 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL397385 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL245653 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL396698 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL247529 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL245282 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL126078 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL248145 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL285527 | — | Ki | = | 1000.0 | nM | 6.00 |