Assay Detail
Binding
CHEMBL887978
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Binding affinity to rat histamine H3 receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new class of histamine H3 receptor antagonists derived from ligand based design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.40 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27979 | A-349,821 | — | 1 | 8.78 |
| CHEMBL425994 | — | — | 1 | 8.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27979 | A-349,821 | Ki | = | 1.66 | nM | 8.78 |
| CHEMBL425994 | — | Ki | = | 9.8 | nM | 8.01 |