Assay Detail
Binding
CHEMBL888088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]SRIF14 from sst1 receptor in rat brain cortex membrane
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 25 | 8.43 | 9.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401290 | — | — | 1 | 9.67 |
| CHEMBL251754 | — | — | 1 | 9.40 |
| CHEMBL440236 | — | — | 1 | 9.39 |
| CHEMBL251753 | — | — | 1 | 9.24 |
| CHEMBL251541 | OBELIN | — | 1 | 9.15 |
| CHEMBL251542 | — | — | 1 | 9.09 |
| CHEMBL248908 | — | — | 1 | 9.08 |
| CHEMBL248907 | — | — | 1 | 8.92 |
| CHEMBL249113 | — | — | 1 | 8.92 |
| CHEMBL399464 | — | — | 1 | 8.92 |
| CHEMBL248715 | — | — | 1 | 8.91 |
| CHEMBL399658 | — | — | 1 | 8.85 |
| CHEMBL399843 | — | — | 1 | 8.81 |
| CHEMBL399267 | — | — | 1 | 8.45 |
| CHEMBL248716 | — | — | 1 | 8.34 |
| CHEMBL251751 | — | — | 1 | 8.32 |
| CHEMBL251752 | — | — | 1 | 8.22 |
| CHEMBL248717 | — | — | 1 | 8.10 |
| CHEMBL401091 | — | — | 1 | 7.80 |
| CHEMBL251334 | — | — | 1 | 7.76 |
| CHEMBL251543 | — | — | 1 | 7.73 |
| CHEMBL251529 | — | — | 1 | 7.60 |
| CHEMBL249111 | — | — | 1 | 7.46 |
| CHEMBL251335 | — | — | 1 | 6.80 |
| CHEMBL249112 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401290 | — | Kd | = | 0.2138 | nM | 9.67 |
| CHEMBL251754 | — | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL440236 | — | Kd | = | 0.4074 | nM | 9.39 |
| CHEMBL251753 | — | Kd | = | 0.5754 | nM | 9.24 |
| CHEMBL251541 | OBELIN | Kd | = | 0.7079 | nM | 9.15 |
| CHEMBL251542 | — | Kd | = | 0.8128 | nM | 9.09 |
| CHEMBL248908 | — | Kd | = | 0.8318 | nM | 9.08 |
| CHEMBL248907 | — | Kd | = | 1.202 | nM | 8.92 |
| CHEMBL249113 | — | Kd | = | 1.202 | nM | 8.92 |
| CHEMBL399464 | — | Kd | = | 1.202 | nM | 8.92 |
| CHEMBL248715 | — | Kd | = | 1.23 | nM | 8.91 |
| CHEMBL399658 | — | Kd | = | 1.413 | nM | 8.85 |
| CHEMBL399843 | — | Kd | = | 1.549 | nM | 8.81 |
| CHEMBL399267 | — | Kd | = | 3.548 | nM | 8.45 |
| CHEMBL248716 | — | Kd | = | 4.571 | nM | 8.34 |
| CHEMBL251751 | — | Kd | = | 4.786 | nM | 8.32 |
| CHEMBL251752 | — | Kd | = | 6.026 | nM | 8.22 |
| CHEMBL248717 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL401091 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL251334 | — | Kd | = | 17.38 | nM | 7.76 |
| CHEMBL251543 | — | Kd | = | 18.62 | nM | 7.73 |
| CHEMBL251529 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL249111 | — | Kd | = | 34.67 | nM | 7.46 |
| CHEMBL251335 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL249112 | — | Kd | = | 1318.26 | nM | 5.88 |