Assay Detail
Binding
CHEMBL888165
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Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: synthesis and binding affinities for 5-HT(7) and 5-HT(1A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.37 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18840 | — | — | 1 | 9.29 |
| CHEMBL238808 | — | — | 1 | 7.60 |
| CHEMBL239656 | — | — | 1 | 7.54 |
| CHEMBL395444 | — | — | 1 | 7.43 |
| CHEMBL239231 | — | — | 1 | 7.39 |
| CHEMBL396396 | — | — | 1 | 7.37 |
| CHEMBL396844 | — | — | 1 | 7.37 |
| CHEMBL396349 | — | — | 1 | 6.92 |
| CHEMBL240729 | — | — | 1 | 6.59 |
| CHEMBL239530 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18840 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL238808 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL239656 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL395444 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL239231 | — | Ki | = | 41.1 | nM | 7.39 |
| CHEMBL396396 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL396844 | — | Ki | = | 42.6 | nM | 7.37 |
| CHEMBL396349 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL240729 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL239530 | — | Ki | = | 573.0 | nM | 6.24 |