Assay Detail
Functional
CHEMBL888167
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Agonist activity at human CB2 in CHO cells assessed as inhibition of cAMP production
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: discovery of CB2 receptor selective compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.89 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | — | 1 | 8.96 |
| CHEMBL232730 | — | — | 1 | 8.21 |
| CHEMBL248135 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL232730 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL248135 | — | IC50 | = | 322.0 | nM | 6.49 |