Assay Detail
Functional
CHEMBL888223
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Inhibition of LPS-stimulated TNFalpha production in human whole blood
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.54 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250504 | — | — | 1 | 4.89 |
| CHEMBL399097 | — | — | 1 | 4.77 |
| CHEMBL250298 | — | — | 1 | 4.72 |
| CHEMBL250710 | — | — | 1 | 4.62 |
| CHEMBL250094 | — | — | 1 | 4.58 |
| CHEMBL250502 | — | — | 1 | 4.57 |
| CHEMBL399098 | — | — | 1 | 4.55 |
| CHEMBL399929 | — | — | 1 | 4.54 |
| CHEMBL250093 | — | — | 1 | 4.47 |
| CHEMBL250299 | — | — | 1 | 4.47 |
| CHEMBL250906 | — | — | 1 | 4.46 |
| CHEMBL250907 | — | — | 1 | 4.44 |
| CHEMBL250709 | — | — | 1 | 4.43 |
| CHEMBL446456 | — | — | 1 | 4.42 |
| CHEMBL250708 | — | — | 1 | 4.41 |
| CHEMBL250503 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250504 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL399097 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL250298 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL250710 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL250094 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL250502 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL399098 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL399929 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL250093 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL250299 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL250906 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL250907 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL250709 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL446456 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL250708 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL250503 | — | IC50 | = | 56000.0 | nM | 4.25 |