Assay Detail
Binding
CHEMBL888229
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Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.89 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 8.31 |
| CHEMBL398948 | — | — | 1 | 7.54 |
| CHEMBL248678 | — | — | 1 | 7.22 |
| CHEMBL251505 | — | — | 1 | 7.22 |
| CHEMBL251709 | — | — | 1 | 7.06 |
| CHEMBL251294 | — | — | 1 | 6.90 |
| CHEMBL251504 | — | — | 1 | 6.87 |
| CHEMBL251710 | — | — | 1 | 6.76 |
| CHEMBL248679 | — | — | 1 | 6.13 |
| CHEMBL2096894 | — | — | 1 | 6.10 |
| CHEMBL398947 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL398948 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL248678 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL251505 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL251709 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL251294 | — | Ki | = | 125.5 | nM | 6.90 |
| CHEMBL251504 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL251710 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL248679 | — | Ki | = | 749.0 | nM | 6.13 |
| CHEMBL2096894 | — | Ki | = | 802.0 | nM | 6.10 |
| CHEMBL398947 | — | Ki | = | 1850.0 | nM | 5.73 |