Compound Detail
CHEMBL398947
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Basic Information
| ChEMBL ID | CHEMBL398947 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HHOFHJTWHYKKJJ-RCFWFJCLSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
313.4
MW (Da)
3.44
ALogP
2
HBA
1
HBD
57.6
PSA (Ų)
0.82
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.35
EC50 1 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP4 subtype CHEMBL1836 | EC50 | 8.4 | 8.4 | 4.0 | 1 |
| Prostaglandin E2 receptor EP4 subtype CHEMBL1836 | Ki | 7.35 | 7.35 | 45.0 | 1 |
| Prostaglandin E2 receptor EP2 subtype CHEMBL1881 | Ki | 5.73 | 5.73 | 1850.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP4 subtype | EC50 | = | 4.0 | nM | 8.4 | Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accu... | 17531488 |
| Prostaglandin E2 receptor EP4 subtype | Ki | = | 45.0 | nM | 7.35 | Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells | 17531488 |
| Prostaglandin E2 receptor EP2 subtype | Ki | = | 1850.0 | nM | 5.73 | Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells | 17531488 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17531488 | 10.1016/j.bmcl.2007.05.025 | Prostaglandin E2 receptor EP4 subtype | 2 |
| 17531488 | 10.1016/j.bmcl.2007.05.025 | Prostaglandin E2 receptor EP2 subtype | 1 |
Data from ChEMBL 36 via Core Engine