Assay Detail
Functional
CHEMBL888281
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Antiproliferative activity against human HCT116 cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.78 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249095 | — | — | 1 | 8.49 |
| CHEMBL248891 | — | — | 1 | 8.00 |
| CHEMBL400859 | — | — | 1 | 7.72 |
| CHEMBL249303 | — | — | 1 | 7.51 |
| CHEMBL249502 | — | — | 1 | 7.38 |
| CHEMBL429478 | — | — | 1 | 7.31 |
| CHEMBL251739 | — | — | 1 | 7.26 |
| CHEMBL400906 | — | — | 1 | 7.26 |
| CHEMBL249096 | — | — | 1 | 7.21 |
| CHEMBL248713 | — | — | 1 | 7.03 |
| CHEMBL248712 | — | — | 1 | 7.02 |
| CHEMBL401064 | — | — | 1 | 6.96 |
| CHEMBL249518 | — | — | 1 | 6.72 |
| CHEMBL251740 | — | — | 1 | 6.70 |
| CHEMBL400568 | — | — | 1 | 6.57 |
| CHEMBL400749 | — | — | 1 | 6.51 |
| CHEMBL249302 | — | — | 1 | 6.48 |
| CHEMBL249304 | — | — | 1 | 6.44 |
| CHEMBL249500 | — | — | 1 | 6.43 |
| CHEMBL249519 | — | — | 1 | 6.36 |
| CHEMBL400569 | — | — | 1 | 6.27 |
| CHEMBL391437 | — | — | 1 | 6.26 |
| CHEMBL248890 | — | — | 1 | 6.05 |
| CHEMBL400858 | — | — | 1 | 5.79 |
| CHEMBL249094 | — | — | 1 | 5.54 |
| CHEMBL399042 | — | — | 1 | 5.10 |
| CHEMBL249501 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249095 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL248891 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL400859 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL249303 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL249502 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL429478 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL251739 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL400906 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL249096 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL248713 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL248712 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL401064 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL249518 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL251740 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL400568 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL400749 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL249302 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL249304 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL249500 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL249519 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL400569 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL391437 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL248890 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL400858 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL249094 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL399042 | — | IC50 | = | 8010.0 | nM | 5.10 |
| CHEMBL249501 | — | IC50 | > | 10000.0 | nM | - |