Assay Detail
Functional
CHEMBL888282
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Antiproliferative activity against human A375 cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248891 | — | — | 1 | 8.00 |
| CHEMBL249095 | — | — | 1 | 7.96 |
| CHEMBL249096 | — | — | 1 | 7.64 |
| CHEMBL400859 | — | — | 1 | 7.48 |
| CHEMBL248712 | — | — | 1 | 7.34 |
| CHEMBL400906 | — | — | 1 | 7.33 |
| CHEMBL249303 | — | — | 1 | 7.33 |
| CHEMBL249502 | — | — | 1 | 7.19 |
| CHEMBL251739 | — | — | 1 | 7.15 |
| CHEMBL429478 | — | — | 1 | 7.00 |
| CHEMBL249519 | — | — | 1 | 6.92 |
| CHEMBL401064 | — | — | 1 | 6.85 |
| CHEMBL249302 | — | — | 1 | 6.80 |
| CHEMBL249304 | — | — | 1 | 6.80 |
| CHEMBL400568 | — | — | 1 | 6.60 |
| CHEMBL251740 | — | — | 1 | 6.58 |
| CHEMBL400749 | — | — | 1 | 6.57 |
| CHEMBL249500 | — | — | 1 | 6.52 |
| CHEMBL249518 | — | — | 1 | 6.48 |
| CHEMBL248713 | — | — | 1 | 6.29 |
| CHEMBL400569 | — | — | 1 | 6.20 |
| CHEMBL391437 | — | — | 1 | 6.06 |
| CHEMBL249094 | — | — | 1 | 6.04 |
| CHEMBL248890 | — | — | 1 | 5.83 |
| CHEMBL400858 | — | — | 1 | 5.76 |
| CHEMBL399042 | — | — | 1 | 5.13 |
| CHEMBL249501 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248891 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL249095 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL249096 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL400859 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL248712 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL400906 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL249303 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL249502 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL251739 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL429478 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL249519 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL401064 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL249302 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL249304 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL400568 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL251740 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL400749 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL249500 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL249518 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL248713 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL400569 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL391437 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL249094 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL248890 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL400858 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL399042 | — | IC50 | = | 7380.0 | nM | 5.13 |
| CHEMBL249501 | — | IC50 | > | 10000.0 | nM | - |