Assay Detail
Binding
CHEMBL888347
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Inhibition of humanized rabbit cathepsin K
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Primary amides as selective inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.38 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437501 | — | — | 1 | 9.70 |
| CHEMBL250501 | — | — | 1 | 9.70 |
| CHEMBL399361 | — | — | 1 | 9.22 |
| CHEMBL250294 | — | — | 1 | 9.05 |
| CHEMBL399359 | — | — | 1 | 8.00 |
| CHEMBL401176 | — | — | 1 | 7.89 |
| CHEMBL427712 | — | — | 1 | 7.57 |
| CHEMBL250904 | — | — | 1 | 7.39 |
| CHEMBL249885 | — | — | 1 | 7.18 |
| CHEMBL250706 | — | — | 1 | 7.17 |
| CHEMBL249275 | — | — | 1 | 7.06 |
| CHEMBL250089 | — | — | 1 | 6.96 |
| CHEMBL251100 | — | — | 1 | 6.92 |
| CHEMBL250293 | — | — | 1 | 6.82 |
| CHEMBL249680 | — | — | 1 | 6.76 |
| CHEMBL248902 | — | — | 1 | 6.62 |
| CHEMBL401175 | — | — | 1 | 6.62 |
| CHEMBL249274 | — | — | 1 | 6.56 |
| CHEMBL249276 | — | — | 1 | 6.56 |
| CHEMBL402267 | — | — | 1 | 5.98 |
| CHEMBL398608 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437501 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL250501 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL399361 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL250294 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL399359 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL401176 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL427712 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL250904 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL249885 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL250706 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL249275 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL250089 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL251100 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL250293 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL249680 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL248902 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL401175 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL249274 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL249276 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL402267 | — | IC50 | = | 1045.0 | nM | 5.98 |
| CHEMBL398608 | — | IC50 | = | 6070.0 | nM | 5.22 |