Assay Detail
Binding
CHEMBL888473
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Displacement of [3H]CCPA from human adenosine A1 receptor in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.94 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388145 | — | — | 1 | 7.26 |
| CHEMBL200732 | — | — | 1 | 6.71 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 6.65 |
| CHEMBL413686 | — | — | 1 | 5.60 |
| CHEMBL373065 | — | — | 1 | 5.23 |
| CHEMBL436485 | — | — | 1 | 5.21 |
| CHEMBL344187 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388145 | — | Ki | = | 55.4 | nM | 7.26 |
| CHEMBL200732 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL413686 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL373065 | — | Ki | = | 5870.0 | nM | 5.23 |
| CHEMBL436485 | — | Ki | = | 6220.0 | nM | 5.21 |
| CHEMBL344187 | — | Ki | = | 12100.0 | nM | 4.92 |