Assay Detail
Binding
CHEMBL888482
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Inhibition of human FAAH expressed in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.87 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427424 | — | — | 1 | 9.35 |
| CHEMBL410598 | — | — | 1 | 9.22 |
| CHEMBL226883 | — | — | 1 | 8.92 |
| CHEMBL227046 | — | — | 1 | 8.54 |
| CHEMBL226938 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427424 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL410598 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL226883 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL227046 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL226938 | — | Ki | = | 5.0 | nM | 8.30 |