Assay Detail
Functional
CHEMBL888532
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Antiviral activity against HIV1 NL4-3 in human PBMC
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Rationally designed dual inhibitors of HIV reverse transcriptase and integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.96 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244167 | — | — | 1 | 8.01 |
| CHEMBL436546 | — | — | 1 | 7.80 |
| CHEMBL243536 | — | — | 1 | 7.77 |
| CHEMBL388707 | — | — | 1 | 7.48 |
| CHEMBL265377 | — | — | 1 | 7.28 |
| CHEMBL242883 | — | — | 1 | 6.80 |
| CHEMBL390489 | — | — | 1 | 5.52 |
| CHEMBL178865 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244167 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL436546 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL243536 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL388707 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL265377 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL242883 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL390489 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL178865 | — | EC50 | = | 8900.0 | nM | 5.05 |