Assay Detail
Binding
CHEMBL888570
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Inhibition of human recombinant glutamate carboxypeptidase 2 by radioenzymatic assay
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.60 | 5.02 |
| Km | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | — | 1 | 5.02 |
| CHEMBL122005 | (S)-WILLARDIINE | — | 1 | 4.17 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | - |
| CHEMBL1329032 | ISOSPAGLUMIC ACID | 2.0 | 1 | - |
| CHEMBL284377 | DEXFOSFOSERINE | 2.0 | 1 | - |
| CHEMBL28885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL122005 | (S)-WILLARDIINE | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL575060 | GLUTAMIC ACID | IC50 | = | 428000.0 | nM | - |
| CHEMBL1329032 | ISOSPAGLUMIC ACID | Km | = | 1200.0 | nM | - |
| CHEMBL284377 | DEXFOSFOSERINE | IC50 | = | 523000.0 | nM | - |
| CHEMBL28885 | — | IC50 | = | 438000.0 | nM | - |