Assay Detail
Functional
CHEMBL888634
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Cytotoxicity against Pgp overexpressing human NCI/ADR cells after 48 hrs by SRB binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel antitumor antimitotic agents that also reverse tumor resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.36 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388289 | — | — | 1 | 6.60 |
| CHEMBL227262 | — | — | 1 | 5.57 |
| CHEMBL388290 | — | — | 1 | 5.24 |
| CHEMBL227263 | — | — | 1 | 4.74 |
| CHEMBL427429 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388289 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL227262 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL388290 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL227263 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL427429 | — | IC50 | = | 21700.0 | nM | 4.66 |