Assay Detail
Binding
CHEMBL888902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane after 90 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.58 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226539 | — | — | 1 | 6.48 |
| CHEMBL226540 | — | — | 1 | 5.97 |
| CHEMBL387741 | — | — | 1 | 5.89 |
| CHEMBL227071 | — | — | 1 | 5.67 |
| CHEMBL226538 | — | — | 1 | 4.82 |
| CHEMBL389261 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226539 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL226540 | — | Ki | = | 1076.0 | nM | 5.97 |
| CHEMBL387741 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL227071 | — | Ki | = | 2150.0 | nM | 5.67 |
| CHEMBL226538 | — | Ki | = | 15300.0 | nM | 4.82 |
| CHEMBL389261 | — | Ki | = | 22750.0 | nM | 4.64 |