Assay Detail
Binding
CHEMBL889062
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human C3a receptor expressed on HMC1 cells by SPA assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HMC1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
C3a anaphylatoxin chemotactic receptor (CHEMBL4761) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new C3aR ligands. Part 1: arginine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.29 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387755 | — | — | 1 | 7.80 |
| CHEMBL229005 | — | — | 1 | 7.50 |
| CHEMBL230034 | — | — | 1 | 7.20 |
| CHEMBL231405 | — | — | 1 | 7.10 |
| CHEMBL231303 | — | — | 1 | 6.90 |
| CHEMBL229006 | — | — | 1 | 6.80 |
| CHEMBL427268 | — | — | 1 | 6.70 |
| CHEMBL231404 | — | — | 1 | 6.70 |
| CHEMBL265866 | — | — | 1 | 6.70 |
| CHEMBL228634 | — | — | 1 | 6.50 |
| CHEMBL394538 | — | — | 1 | 6.50 |
| CHEMBL389349 | — | — | 1 | 6.50 |
| CHEMBL389348 | — | — | 1 | 6.30 |
| CHEMBL228582 | — | — | 1 | 6.10 |
| CHEMBL394539 | — | — | 1 | 6.10 |
| CHEMBL228847 | — | — | 1 | 6.10 |
| CHEMBL228901 | — | — | 1 | 6.10 |
| CHEMBL387686 | — | — | 1 | 5.80 |
| CHEMBL228635 | — | — | 1 | 5.40 |
| CHEMBL390834 | — | — | 1 | 5.20 |
| CHEMBL228900 | — | — | 1 | 4.30 |
| CHEMBL228846 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387755 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL229005 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL230034 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL231405 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL231303 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL229006 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL427268 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL231404 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL265866 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL228634 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL394538 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL389349 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL389348 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL228582 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL394539 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL228847 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL228901 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL387686 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL228635 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL390834 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL228900 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL228846 | — | IC50 | = | 100000.0 | nM | 4.00 |