Assay Detail

CHEMBL889159

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Functional

Antagonist activity at human histamine H3 receptor

ChEMBL ↗

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Target

Histamine H3 receptor (CHEMBL264) ↗

Open DB target context

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Primary target Histamine H3 receptor

CHEMBL264

Anchored from Assay target.

Protein identity Histamine H3 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Histamine H3 receptor (CHEMBL264) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

A new class of histamine H3 receptor antagonists derived from ligand based design.

Roche O, Rodríguez Sarmiento RM.
Bioorg Med Chem Lett (2007) 17 : 3670 -3675
PubMed 17498953 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	9.84	9.84

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL129542	JNJ-5207852	—	1	9.84

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL129542	JNJ-5207852	Kd	=	0.1445	nM	9.84