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Assay Detail

CHEMBL889245

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Functional
Cytotoxicity against human MIA PaCa cells by MTT assay
ChEMBL ↗
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PaCa
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
Zhu GD, Gandhi VB, Gong J, Thomas S, Woods KW, Song X, Li T, Diebold RB, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Bouska J, Olson A, Marsh KC, Stoll VS, Mamo M, Polakowski J, Campbell TJ, Martin RL, Gintant GA, Penning TD, Li Q, Rosenberg SH, Giranda VL.
J Med Chem (2007) 50 : 2990 -3003
PubMed 17523610 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 54 6.12 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL438483 — — 1 6.75
CHEMBL229918 — — 1 6.68
CHEMBL226577 — — 1 6.64
CHEMBL226529 — — 1 6.64
CHEMBL227368 — — 1 6.62
CHEMBL226745 — — 1 6.60
CHEMBL427422 — — 1 6.58
CHEMBL229314 — — 1 6.58
CHEMBL229917 — — 1 6.57
CHEMBL229798 — — 1 6.54
CHEMBL227050 — — 1 6.48
CHEMBL376394 — — 1 6.47
CHEMBL229854 — — 1 6.47
CHEMBL226898 — — 1 6.43
CHEMBL390372 — — 1 6.43
CHEMBL390371 — — 1 6.42
CHEMBL227367 — — 1 6.37
CHEMBL229800 — — 1 6.36
CHEMBL229799 — — 1 6.35
CHEMBL229968 — — 1 6.31
CHEMBL227325 — — 1 6.24
CHEMBL226627 — — 1 6.22
CHEMBL226625 — — 1 6.22
CHEMBL379218 — — 1 6.19
CHEMBL227326 — — 1 6.17
CHEMBL375919 — — 1 6.17
CHEMBL229855 — — 1 6.16
CHEMBL229320 — — 1 6.09
CHEMBL227271 — — 1 6.08
CHEMBL227366 — — 1 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL438483 — EC50 = 180.0 nM 6.75
CHEMBL229918 — EC50 = 210.0 nM 6.68
CHEMBL226529 — EC50 = 230.0 nM 6.64
CHEMBL226577 — EC50 = 230.0 nM 6.64
CHEMBL227368 — EC50 = 240.0 nM 6.62
CHEMBL226745 — EC50 = 250.0 nM 6.60
CHEMBL427422 — EC50 = 260.0 nM 6.58
CHEMBL229314 — EC50 = 260.0 nM 6.58
CHEMBL229917 — EC50 = 270.0 nM 6.57
CHEMBL229798 — EC50 = 290.0 nM 6.54
CHEMBL227050 — EC50 = 330.0 nM 6.48
CHEMBL376394 — EC50 = 340.0 nM 6.47
CHEMBL229854 — EC50 = 340.0 nM 6.47
CHEMBL226898 — EC50 = 370.0 nM 6.43
CHEMBL390372 — EC50 = 370.0 nM 6.43
CHEMBL390371 — EC50 = 380.0 nM 6.42
CHEMBL227367 — EC50 = 430.0 nM 6.37
CHEMBL229800 — EC50 = 440.0 nM 6.36
CHEMBL229799 — EC50 = 450.0 nM 6.35
CHEMBL229968 — EC50 = 490.0 nM 6.31
CHEMBL227325 — EC50 = 580.0 nM 6.24
CHEMBL226627 — EC50 = 600.0 nM 6.22
CHEMBL226625 — EC50 = 600.0 nM 6.22
CHEMBL379218 — EC50 = 640.0 nM 6.19
CHEMBL375919 — EC50 = 670.0 nM 6.17
CHEMBL227326 — EC50 = 680.0 nM 6.17
CHEMBL229855 — EC50 = 700.0 nM 6.16
CHEMBL229320 — EC50 = 810.0 nM 6.09
CHEMBL227271 — EC50 = 830.0 nM 6.08
CHEMBL227366 — EC50 = 900.0 nM 6.05
CHEMBL229315 — EC50 = 930.0 nM 6.03
CHEMBL227322 — EC50 = 970.0 nM 6.01
CHEMBL376118 — EC50 = 1000.0 nM 6.00
CHEMBL427426 — EC50 = 1070.0 nM 5.97
CHEMBL226996 — EC50 = 1260.0 nM 5.90
CHEMBL226797 — EC50 = 1250.0 nM 5.90
CHEMBL375716 — EC50 = 1380.0 nM 5.86
CHEMBL388312 — EC50 = 1380.0 nM 5.86
CHEMBL375717 — EC50 = 1430.0 nM 5.84
CHEMBL227051 — EC50 = 1610.0 nM 5.79
CHEMBL227324 — EC50 = 1700.0 nM 5.77
CHEMBL226850 — EC50 = 2390.0 nM 5.62
CHEMBL388310 — EC50 = 2740.0 nM 5.56
CHEMBL227323 — EC50 = 2900.0 nM 5.54
CHEMBL226744 — EC50 = 3700.0 nM 5.43
CHEMBL226798 — EC50 = 4800.0 nM 5.32
CHEMBL415220 — EC50 = 13000.0 nM 4.89
CHEMBL226796 — EC50 = 16500.0 nM 4.78
CHEMBL226626 — EC50 - — -
CHEMBL389438 — EC50 - — -