Assay Detail
Functional
CHEMBL889369
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL432
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.63 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396465 | — | — | 1 | 8.03 |
| CHEMBL396462 | — | — | 1 | 7.80 |
| CHEMBL414775 | — | — | 1 | 7.77 |
| CHEMBL396334 | — | — | 1 | 7.77 |
| CHEMBL230484 | — | — | 1 | 7.77 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.60 |
| CHEMBL414959 | — | — | 1 | 7.16 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396465 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL396462 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL414775 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL396334 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL230484 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL414959 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL163 | RITONAVIR | EC50 | = | 80.0 | nM | 7.10 |