Assay Detail
Functional
CHEMBL889372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against ritonavir and nelfinavir-resistant HIV1 NL432
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.47 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396465 | — | — | 1 | 7.89 |
| CHEMBL230484 | — | — | 1 | 7.85 |
| CHEMBL414775 | — | — | 1 | 7.64 |
| CHEMBL396462 | — | — | 1 | 7.64 |
| CHEMBL396334 | — | — | 1 | 7.50 |
| CHEMBL414959 | — | — | 1 | 7.28 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.17 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396465 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL230484 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL414775 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL396462 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL396334 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL414959 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL163 | RITONAVIR | EC50 | = | 162.0 | nM | 6.79 |