Assay Detail
Binding
CHEMBL889424
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Inhibition of His-tagged HDAC10 expressed in Sf9 cells by fluorescence-based assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.36 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387924 | — | — | 1 | 7.96 |
| CHEMBL389688 | — | — | 1 | 7.55 |
| CHEMBL227170 | — | — | 1 | 7.38 |
| CHEMBL389687 | — | — | 1 | 7.34 |
| CHEMBL227118 | — | — | 1 | 6.76 |
| CHEMBL227120 | — | — | 1 | 6.75 |
| CHEMBL227119 | — | — | 1 | 6.75 |
| CHEMBL180911 | — | — | 1 | 5.81 |
| CHEMBL440018 | — | — | 1 | 5.46 |
| CHEMBL180064 | — | — | 1 | 5.06 |
| CHEMBL178456 | — | — | 1 | 4.97 |
| CHEMBL427510 | — | — | 1 | 4.53 |
| CHEMBL427135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387924 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL389688 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL227170 | — | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL389687 | — | IC50 | = | 46.1 | nM | 7.34 |
| CHEMBL227118 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL227120 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL227119 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL180911 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL440018 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL180064 | — | IC50 | = | 8780.0 | nM | 5.06 |
| CHEMBL178456 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL427510 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL427135 | — | IC50 | > | 30000.0 | nM | - |