Assay Detail
Binding
CHEMBL889554
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Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as effect on (S)-AMPA-induced current
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.71 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61593 | CYCLOTHIAZIDE | 4.0 | 1 | 5.15 |
| CHEMBL103741 | — | — | 1 | 4.66 |
| CHEMBL375913 | — | — | 1 | 4.55 |
| CHEMBL411612 | — | — | 1 | 4.48 |
| CHEMBL320642 | — | — | 1 | - |
| CHEMBL77862 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61593 | CYCLOTHIAZIDE | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL103741 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL375913 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL411612 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL320642 | — | EC50 | = | 130000.0 | nM | - |
| CHEMBL77862 | — | EC50 | - | — | - |