Assay Detail
Binding
CHEMBL889784
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Displacement of Dexamethasone from human glucocorticoid receptor by fluorescence polarization assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.63 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395506 | — | — | 1 | 7.47 |
| CHEMBL541908 | — | — | 1 | 7.40 |
| CHEMBL379024 | — | — | 1 | 7.08 |
| CHEMBL537887 | — | — | 1 | 6.96 |
| CHEMBL228610 | — | — | 1 | 6.94 |
| CHEMBL396997 | — | — | 1 | 6.94 |
| CHEMBL430004 | — | — | 1 | 6.73 |
| CHEMBL206278 | — | — | 1 | 6.72 |
| CHEMBL382785 | — | — | 1 | 6.71 |
| CHEMBL242675 | — | — | 1 | 6.71 |
| CHEMBL397018 | — | — | 1 | 6.68 |
| CHEMBL228932 | — | — | 1 | 6.58 |
| CHEMBL242872 | — | — | 1 | 6.56 |
| CHEMBL388017 | — | — | 1 | 6.54 |
| CHEMBL228611 | — | — | 1 | 6.45 |
| CHEMBL203885 | — | — | 1 | 6.44 |
| CHEMBL394343 | — | — | 1 | 6.40 |
| CHEMBL395051 | — | — | 1 | 6.40 |
| CHEMBL394345 | — | — | 1 | 6.39 |
| CHEMBL228878 | — | — | 1 | 6.25 |
| CHEMBL395535 | — | — | 1 | 6.15 |
| CHEMBL394344 | — | — | 1 | 6.01 |
| CHEMBL228767 | — | — | 1 | 5.97 |
| CHEMBL228661 | — | — | 1 | - |
| CHEMBL228663 | — | — | 1 | - |
| CHEMBL395536 | — | — | 1 | - |
| CHEMBL228715 | — | — | 1 | - |
| CHEMBL228766 | — | — | 1 | - |
| CHEMBL388170 | — | — | 1 | - |
| CHEMBL202897 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395506 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL541908 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL379024 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL537887 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL228610 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL396997 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL430004 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL206278 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL382785 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL242675 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL397018 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL228932 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL242872 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL388017 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL228611 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL203885 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL394343 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL395051 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL394345 | — | IC50 | = | 404.0 | nM | 6.39 |
| CHEMBL228878 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL395535 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL394344 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL228767 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL228661 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL228663 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL395536 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL228715 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL228766 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL388170 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL202897 | — | IC50 | > | 2000.0 | nM | - |