Assay Detail
Functional
CHEMBL889788
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Inhibition of IL1-induced IL6 production in foreskin fibroblasts after 24 hrs
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.68 | 6.77 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541908 | — | — | 1 | 6.77 |
| CHEMBL537887 | — | — | 1 | 6.58 |
| CHEMBL206278 | — | — | 1 | - |
| CHEMBL395506 | — | — | 1 | - |
| CHEMBL379024 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541908 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL537887 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL206278 | — | Activity | - | — | - | |
| CHEMBL395506 | — | IC50 | - | — | - | |
| CHEMBL379024 | — | Activity | - | — | - |