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Target Snapshot

CHEMBL613838 Target Snapshot

Fibroblast · CELL-LINE

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238Compounds
148Assays
3Approved Drugs
72.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Fibroblast as ChEMBL target CHEMBL613838. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Fibroblast
CELL-LINE
As of 2026-09-14
ChEMBL target ID
CHEMBL613838
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Fibroblast still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameFibroblast
Target TypeCELL-LINE
OrganismNone
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFibroblast
UniProt AccessionN/A

Fibroblast

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Fibroblast.

Review nameFibroblast
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5070.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1223852 7.44 EC50 36.0 Preclinical
CHEMBL541908 6.77 IC50 170.0 Preclinical
CHEMBL537887 6.58 IC50 260.0 Preclinical
CHEMBL5435800 6.58 IC50 264.0 Preclinical
CHEMBL252556 6.23 EC50 592.0 Approved
CHEMBL288064 6.2 IC50 625.0 Preclinical
CHEMBL142711 6.19 IC50 650.0 Preclinical
CHEMBL270509 6.11 IC50 780.0 Preclinical
CHEMBL63354 5.75 IC50 1800.0 Preclinical
CHEMBL226630 5.68 IC50 2100.0 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
5
5.5
4
6.0
3
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

IDEBENONE
CHEMBL252556
Approved 2015
Properties Compare Identifier
Assay Landscape

Assay Landscape

148
Total Assays
26
Tested Compounds
3
Assay Types
Functional — 120 assays, 26 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 120 26 5.3
ADME — 18 assays, 8 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 18 8 4.7
Toxicity — 10 assays, 15 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 15 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine