Compound Detail
CHEMBL270509
SUMAFLAVONE Enter ChEMBL ID:
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O=c1cc(-c2ccc(O)c(-c3c(O)c(O)c(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12
Basic Information
| ChEMBL ID | CHEMBL270509 |
| Name | SUMAFLAVONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BCTLOSNRPJXRNV-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
554.5
MW (Da)
4.84
ALogP
11
HBA
7
HBD
202.0
PSA (Ų)
0.15
QED
3
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast CHEMBL613838 | IC50 | 6.11 | 6.11 | 780.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast | IC50 | = | 780.0 | nM | 6.11 | Inhibition of UVB irradiation-induced MMP1 production in human dermal fibroblast... | 18029185 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18029185 | 10.1016/j.bmc.2007.10.036 | Fibroblast | 6 |
| 18029185 | 10.1016/j.bmc.2007.10.036 | 72 kDa type IV collagenase | 1 |
Data from ChEMBL 36 via Core Engine