Assay Detail
Functional
CHEMBL945958
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Inhibition of UVB irradiation-induced MMP1 production in human dermal fibroblasts after 48 hrs
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.62 | 6.11 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270509 | SUMAFLAVONE | — | 2 | 6.11 |
| CHEMBL63354 | AMENTOFLAVONE | — | 2 | 5.75 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270509 | SUMAFLAVONE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL63354 | AMENTOFLAVONE | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL38 | TRETINOIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL270509 | SUMAFLAVONE | Activity | - | — | - | |
| CHEMBL63354 | AMENTOFLAVONE | Activity | - | — | - |