Assay Detail
Functional
CHEMBL889841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT1080 cells by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity studies of antofine analogues as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.56 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244970 | — | — | 1 | 8.96 |
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 8.02 |
| CHEMBL396203 | — | — | 1 | 7.70 |
| CHEMBL242814 | — | — | 1 | 7.63 |
| CHEMBL244969 | (+/-)-ANTOFINE | — | 1 | 7.56 |
| CHEMBL396202 | — | — | 1 | 7.43 |
| CHEMBL389340 | — | — | 1 | 7.23 |
| CHEMBL242815 | — | — | 1 | 7.14 |
| CHEMBL243035 | — | — | 1 | 6.34 |
| CHEMBL430000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244970 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL396203 | — | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL242814 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL244969 | (+/-)-ANTOFINE | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL396202 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL389340 | — | IC50 | = | 59.1 | nM | 7.23 |
| CHEMBL242815 | — | IC50 | = | 72.6 | nM | 7.14 |
| CHEMBL243035 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL430000 | — | IC50 | > | 1000.0 | nM | - |