Assay Detail
Binding
CHEMBL890042
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Displacement of [125I]MDC from human CCR4 expressed in HEK293 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Core exploration in optimization of chemokine receptor CCR4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.28 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233046 | — | — | 1 | 7.70 |
| CHEMBL372399 | — | — | 1 | 7.30 |
| CHEMBL394859 | — | — | 1 | 7.10 |
| CHEMBL397028 | — | — | 1 | 6.85 |
| CHEMBL233047 | — | — | 1 | 6.55 |
| CHEMBL396787 | — | — | 1 | 6.55 |
| CHEMBL233045 | — | — | 1 | 6.30 |
| CHEMBL232839 | — | — | 1 | 6.09 |
| CHEMBL232840 | — | — | 1 | 6.08 |
| CHEMBL396786 | — | — | 1 | 5.96 |
| CHEMBL232841 | — | — | 1 | 5.72 |
| CHEMBL232639 | — | — | 1 | 5.68 |
| CHEMBL232641 | — | — | 1 | 5.58 |
| CHEMBL233261 | — | — | 1 | 5.44 |
| CHEMBL232640 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233046 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL372399 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL394859 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL397028 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL233047 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL396787 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL233045 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL232839 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL232840 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL396786 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL232841 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL232639 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL232641 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL233261 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL232640 | — | IC50 | = | 4900.0 | nM | 5.31 |