Assay Detail
Binding
CHEMBL890074
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Inhibition of rat microsomal VKER
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of novel warfarin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.89 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242824 | GERANYLGERANYLCOUMARIN | — | 1 | 7.09 |
| CHEMBL174839 | FERULENOL | — | 1 | 7.01 |
| CHEMBL242826 | — | — | 1 | 6.89 |
| CHEMBL233451 | BRODIFACOUM | — | 1 | 6.82 |
| CHEMBL241896 | GERANYLCOUMARIN | — | 1 | 6.77 |
| CHEMBL242825 | DIMETHYLFERULENOL | — | 1 | 6.47 |
| CHEMBL397420 | ACENOCOUMAROL | 3.0 | 1 | 6.11 |
| CHEMBL245138 | OLEYLCOUMARIN | — | 1 | 6.05 |
| CHEMBL1465 | PHENPROCOUMON | 4.0 | 1 | 5.75 |
| CHEMBL1464 | WARFARIN | 4.0 | 1 | 5.66 |
| CHEMBL233244 | — | — | 1 | 5.52 |
| CHEMBL1466 | DICUMAROL | 4.0 | 1 | 5.51 |
| CHEMBL232230 | WARFARIN ALCOHOL | — | 1 | 4.90 |
| CHEMBL148730 | — | — | 1 | 4.89 |
| CHEMBL397422 | — | — | 1 | 4.74 |
| CHEMBL397932 | ISOPRENYLCOUMARIN | — | 1 | 4.10 |
| CHEMBL329819 | — | — | 1 | - |
| CHEMBL395980 | — | — | 1 | - |
| CHEMBL233041 | — | — | 1 | - |
| CHEMBL232635 | — | — | 1 | - |
| CHEMBL232232 | WARFARIN TRIFLATE | — | 1 | - |
| CHEMBL145880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242824 | GERANYLGERANYLCOUMARIN | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL174839 | FERULENOL | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL242826 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL233451 | BRODIFACOUM | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL241896 | GERANYLCOUMARIN | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL242825 | DIMETHYLFERULENOL | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL397420 | ACENOCOUMAROL | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL245138 | OLEYLCOUMARIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1465 | PHENPROCOUMON | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1464 | WARFARIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL233244 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1466 | DICUMAROL | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL232230 | WARFARIN ALCOHOL | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL148730 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL397422 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL397932 | ISOPRENYLCOUMARIN | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL329819 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL395980 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL233041 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL232635 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL232232 | WARFARIN TRIFLATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL145880 | — | IC50 | = | 250000.0 | nM | - |