Compound Detail
CHEMBL397420
ACENOCOUMAROL 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL397420 |
| Name | ACENOCOUMAROL |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | VABCILAOYCMVPS-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
20
Publications
5
Known Names
4
Indications
1
Mechanisms
Molecular Properties
353.3
MW (Da)
3.52
ALogP
6
HBA
1
HBD
110.7
PSA (Ų)
0.43
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor | INHIBITOR | Vitamin K epoxide reductase complex subunit 1 | ✓ | ✓ |
Indications
Thrombosis Atrial Fibrillation Pulmonary Embolism Melanoma
ATC Classification
B01AA07
acenocoumarol
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: ANTITHROMBOTIC AGENTS
Activity Summary
IC50 1 meas. best 6.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.11 | 6.11 | 770.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 37.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 770.0 | nM | 6.11 | Inhibition of rat microsomal VKER | 17275317 |
Literature References
Data from ChEMBL 36 via Core Engine