Assay Detail
Functional
CHEMBL890164
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RF in CEM-SS cells by XTT assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.69 | 7.70 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226735 | — | — | 1 | 7.70 |
| CHEMBL428685 | — | — | 1 | 6.60 |
| CHEMBL389466 | — | — | 1 | 6.30 |
| CHEMBL226787 | — | — | 1 | 6.16 |
| CHEMBL267920 | — | — | 1 | - |
| CHEMBL226788 | — | — | 1 | - |
| CHEMBL226786 | — | — | 1 | - |
| CHEMBL389237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226735 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL428685 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL389466 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL226787 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL267920 | — | Activity | - | — | - | |
| CHEMBL226788 | — | Activity | - | — | - | |
| CHEMBL226786 | — | Activity | - | — | - | |
| CHEMBL389237 | — | Activity | - | — | - |