Assay Detail
Binding
CHEMBL890185
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Inhibition of steroid sulfatase in JEG3 cell membrane
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | JEG-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual aromatase-steroid sulfatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.89 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286738 | IROSUSTAT | 2.0 | 1 | 8.82 |
| CHEMBL390496 | — | — | 1 | 6.72 |
| CHEMBL226736 | — | — | 1 | 6.42 |
| CHEMBL390717 | — | — | 1 | 6.27 |
| CHEMBL226892 | — | — | 1 | 6.23 |
| CHEMBL108425 | — | — | 1 | - |
| CHEMBL226945 | — | — | 1 | - |
| CHEMBL226893 | — | — | 1 | - |
| CHEMBL390077 | — | — | 1 | - |
| CHEMBL226737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286738 | IROSUSTAT | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL390496 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL226736 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL390717 | — | IC50 | = | 536.0 | nM | 6.27 |
| CHEMBL226892 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL108425 | — | IC50 | - | — | - | |
| CHEMBL226945 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL226893 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL390077 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL226737 | — | IC50 | > | 10000.0 | nM | - |