Assay Detail
Binding
CHEMBL890213
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]clonidine from adrenergic alpha2 receptor in Sprague-Dawley rat cortex membrane
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.41 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243176 | — | — | 1 | 7.96 |
| CHEMBL41749 | — | — | 1 | 7.80 |
| CHEMBL287837 | — | — | 1 | 7.68 |
| CHEMBL130744 | — | — | 1 | 7.11 |
| CHEMBL243836 | — | — | 1 | 7.00 |
| CHEMBL243835 | — | — | 1 | 6.80 |
| CHEMBL281864 | — | — | 1 | 6.64 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | 6.46 |
| CHEMBL243834 | — | — | 1 | 6.39 |
| CHEMBL390453 | — | — | 1 | 6.23 |
| CHEMBL338311 | — | — | 1 | 6.08 |
| CHEMBL413311 | — | — | 1 | 5.54 |
| CHEMBL281289 | — | — | 1 | 5.37 |
| CHEMBL27162 | — | — | 1 | 5.14 |
| CHEMBL26717 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243176 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL41749 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL287837 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL130744 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL243836 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL243835 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL281864 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL243834 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL390453 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL338311 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL413311 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL281289 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL27162 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL26717 | — | Ki | = | 100000.0 | nM | 4.00 |