Assay Detail

CHEMBL890263

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Functional

Inhibition of hypoxia-induced HIF1alpha accumulation in Hep3B cells

ChEMBL ↗

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Target

Hep 3B2 (CHEMBL4296437) ↗

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Primary target Hep 3B2

CHEMBL4296437

Anchored from Assay target.

Protein identity Hep 3B2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Hep 3B2
Confidence	1 — Organism
Curated By	Autocuration

Target

Hep 3B2 (CHEMBL4296437) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.

Dat NT, Jin X, Lee JH, Lee D, Hong YS, Lee K, Kim YH, Lee JJ.
J Nat Prod (2007) 70 : 1093 -1097
PubMed 17583950 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.95	6.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL388964	SIBIRIQUINONE A	—	1	6.40
CHEMBL227075	DIHYDROTANSHINONE I	—	1	5.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL388964	SIBIRIQUINONE A	IC50	=	400.0	nM	6.40
CHEMBL227075	DIHYDROTANSHINONE I	IC50	=	3200.0	nM	5.50