Assay Detail
Binding
CHEMBL890266
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Binding affinity to glucocorticoid receptor by GR binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Endiandrin A, a potent glucocorticoid receptor binder isolated from the Australian plant Endiandra anthropophagorum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.89 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228274 | ENDIANDRIN A | — | 1 | 6.05 |
| CHEMBL388363 | DI-O-METHYLENDIANDRIN A | — | 1 | 4.89 |
| CHEMBL228326 | NECTANDRIN B | — | 1 | 4.57 |
| CHEMBL228655 | DI-O-ACETYLENDIANDRIN A | — | 1 | 4.47 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228274 | ENDIANDRIN A | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL388363 | DI-O-METHYLENDIANDRIN A | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL228326 | NECTANDRIN B | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL228655 | DI-O-ACETYLENDIANDRIN A | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | IC50 | = | 35000.0 | nM | 4.46 |