Assay Detail
Functional
CHEMBL890274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against multidrug resistant human KB-Vin cells by SRB microtiter plate assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.65 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 8.05 |
| CHEMBL512688 | — | — | 1 | 7.40 |
| CHEMBL1204387 | — | — | 1 | 7.05 |
| CHEMBL231594 | — | — | 1 | 7.05 |
| CHEMBL1170883 | — | — | 1 | 6.80 |
| CHEMBL395996 | — | — | 1 | 6.80 |
| CHEMBL469780 | — | — | 1 | 6.70 |
| CHEMBL229034 | — | — | 1 | 6.47 |
| CHEMBL231495 | — | — | 1 | 6.46 |
| CHEMBL397460 | — | — | 1 | 6.42 |
| CHEMBL429965 | — | — | 1 | 6.30 |
| CHEMBL396059 | — | — | 1 | 6.29 |
| CHEMBL231493 | — | — | 1 | 6.08 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 5.28 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL512688 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1204387 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL231594 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1170883 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL395996 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL469780 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL229034 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL231495 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL397460 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL429965 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL396059 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL231493 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL50588 | EMETINE | IC50 | > | 2000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | IC50 | > | 4000.0 | nM | - |
| CHEMBL44657 | ETOPOSIDE | IC50 | > | 10000.0 | nM | - |