Assay Detail
Functional
CHEMBL890377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 with RT 103N mutant assessed as inhibition of viral-induced cytopathicity in MT4 cells by MTT method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationship in the 3-iodo-4-phenoxypyridinone (IOPY) series: The nature of the C-3 substituent on anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.39 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234283 | — | — | 1 | 8.51 |
| CHEMBL233664 | — | — | 1 | 8.50 |
| CHEMBL233663 | — | — | 1 | 7.90 |
| CHEMBL234282 | — | — | 1 | 7.70 |
| CHEMBL233452 | — | — | 1 | 7.50 |
| CHEMBL234077 | — | — | 1 | 7.40 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.40 |
| CHEMBL397934 | — | — | 1 | 7.40 |
| CHEMBL395522 | — | — | 1 | 7.40 |
| CHEMBL233662 | — | — | 1 | 7.10 |
| CHEMBL234285 | — | — | 1 | 6.70 |
| CHEMBL234284 | — | — | 1 | 6.50 |
| CHEMBL233453 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234283 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL233664 | — | IC50 | = | 3.16 | nM | 8.50 |
| CHEMBL233663 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL234282 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL233452 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL234077 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL397934 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL395522 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL233662 | — | IC50 | = | 79.4 | nM | 7.10 |
| CHEMBL234285 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL234284 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL233453 | — | IC50 | = | 794.0 | nM | 6.10 |