Assay Detail
Binding
CHEMBL890414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant caspase 3
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.83 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227036 | — | — | 1 | 8.44 |
| CHEMBL227035 | — | — | 1 | 8.41 |
| CHEMBL387556 | — | — | 1 | 8.29 |
| CHEMBL226828 | — | — | 1 | 8.12 |
| CHEMBL427284 | — | — | 1 | 8.11 |
| CHEMBL226881 | — | — | 1 | 8.11 |
| CHEMBL376112 | — | — | 1 | 8.01 |
| CHEMBL213759 | — | — | 1 | 8.01 |
| CHEMBL436989 | — | — | 1 | 7.70 |
| CHEMBL226779 | — | — | 1 | 7.56 |
| CHEMBL427283 | — | — | 1 | 7.50 |
| CHEMBL390932 | — | — | 1 | 6.92 |
| CHEMBL376760 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227036 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL227035 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL387556 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL226828 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL427284 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL226881 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL376112 | — | IC50 | = | 9.85 | nM | 8.01 |
| CHEMBL213759 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL436989 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL226779 | — | IC50 | = | 27.8 | nM | 7.56 |
| CHEMBL427283 | — | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL390932 | — | IC50 | = | 119.3 | nM | 6.92 |
| CHEMBL376760 | — | IC50 | = | 272.0 | nM | 6.57 |