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Assay Detail

CHEMBL890420

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 in human PBM cells
24
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type PBM
Confidence 1 — Organism
Curated By Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
Amblard F, Govindarajan B, Lefkove B, Rapp KL, Detorio M, Arbiser JL, Schinazi RF.
Bioorg Med Chem Lett (2007) 17 : 4428 -4431
PubMed 17587572 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 4.77 5.48
EC90 12 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL16901 HONOKIOL 2 5.48
CHEMBL230240 2 5.39
CHEMBL230346 2 5.02
CHEMBL231491 2 4.87
CHEMBL230242 2 4.84
CHEMBL231391 2 4.71
CHEMBL389317 2 4.63
CHEMBL230345 2 4.46
CHEMBL182529 2 4.46
CHEMBL230241 2 4.44
CHEMBL180920 MAGNOLOL 2 4.16
CHEMBL230556 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL16901 HONOKIOL EC50 = 3300.0 nM 5.48
CHEMBL230240 EC50 = 4100.0 nM 5.39
CHEMBL230346 EC50 = 9500.0 nM 5.02
CHEMBL231491 EC50 = 13600.0 nM 4.87
CHEMBL230242 EC50 = 14300.0 nM 4.84
CHEMBL231391 EC50 = 19400.0 nM 4.71
CHEMBL389317 EC50 = 23400.0 nM 4.63
CHEMBL182529 EC50 = 34800.0 nM 4.46
CHEMBL230345 EC50 = 35000.0 nM 4.46
CHEMBL230241 EC50 = 36500.0 nM 4.44
CHEMBL180920 MAGNOLOL EC50 = 69300.0 nM 4.16
CHEMBL180920 MAGNOLOL EC90 > 100.0 uM -
CHEMBL230346 EC90 = 30.9 uM -
CHEMBL230345 EC90 = 67.2 uM -
CHEMBL230242 EC90 = 48.8 uM -
CHEMBL230241 EC90 = 67.2 uM -
CHEMBL230240 EC90 = 47.3 uM -
CHEMBL231491 EC90 = 35.1 uM -
CHEMBL231391 EC90 = 66.4 uM -
CHEMBL182529 EC90 = 63.0 uM -
CHEMBL230556 EC50 > 100000.0 nM -
CHEMBL230556 EC90 > 100.0 uM -
CHEMBL389317 EC90 = 81.0 uM -
CHEMBL16901 HONOKIOL EC90 = 22.7 uM -