Assay Detail
ADMET
CHEMBL890421
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PBM cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBM |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.48 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16901 | HONOKIOL | — | 1 | 4.79 |
| CHEMBL230345 | — | — | 1 | 4.78 |
| CHEMBL230556 | — | — | 1 | 4.50 |
| CHEMBL231491 | — | — | 1 | 4.47 |
| CHEMBL389317 | — | — | 1 | 4.43 |
| CHEMBL180920 | MAGNOLOL | — | 1 | 4.41 |
| CHEMBL230242 | — | — | 1 | 4.36 |
| CHEMBL182529 | — | — | 1 | 4.34 |
| CHEMBL230241 | — | — | 1 | 4.26 |
| CHEMBL230346 | — | — | 1 | - |
| CHEMBL230240 | — | — | 1 | - |
| CHEMBL231391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16901 | HONOKIOL | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL230345 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL230556 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL231491 | — | IC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL389317 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL180920 | MAGNOLOL | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL230242 | — | IC50 | = | 43600.0 | nM | 4.36 |
| CHEMBL182529 | — | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL230241 | — | IC50 | = | 55400.0 | nM | 4.26 |
| CHEMBL230346 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL230240 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL231391 | — | IC50 | > | 100000.0 | nM | - |