Assay Detail
Binding
CHEMBL890489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PDBu from mouse recombinant PKCalpha expressed in Escherichia coli
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.27 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96766 | — | — | 1 | 8.54 |
| CHEMBL230048 | — | — | 1 | 8.51 |
| CHEMBL231617 | — | — | 1 | 8.46 |
| CHEMBL2096884 | — | — | 1 | 8.24 |
| CHEMBL2096883 | — | — | 1 | 8.19 |
| CHEMBL231141 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96766 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL230048 | — | Ki | = | 3.07 | nM | 8.51 |
| CHEMBL231617 | — | Ki | = | 3.49 | nM | 8.46 |
| CHEMBL2096884 | — | Ki | = | 5.78 | nM | 8.24 |
| CHEMBL2096883 | — | Ki | = | 6.41 | nM | 8.19 |
| CHEMBL231141 | — | Ki | = | 19.83 | nM | 7.70 |