Assay Detail
ADMET
CHEMBL890508
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Growth inhibition of human WI38 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | WI-38 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bioactive cardenolides from the stems and twigs of Nerium oleander.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.18 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.40 |
| CHEMBL229259 | — | — | 1 | 4.16 |
| CHEMBL413068 | — | — | 1 | 4.10 |
| CHEMBL229258 | — | — | 1 | 4.05 |
| CHEMBL229533 | — | — | 1 | - |
| CHEMBL374839 | — | — | 1 | - |
| CHEMBL229260 | — | — | 1 | - |
| CHEMBL375720 | — | — | 1 | - |
| CHEMBL229373 | — | — | 1 | - |
| CHEMBL375518 | — | — | 1 | - |
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | - |
| CHEMBL1162954 | — | — | 1 | - |
| CHEMBL229203 | — | — | 1 | - |
| CHEMBL388861 | — | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL229259 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL413068 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL229258 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL229533 | — | IC50 | < | 20000.0 | nM | - |
| CHEMBL374839 | — | IC50 | = | 1700000.0 | nM | - |
| CHEMBL229260 | — | IC50 | = | 9400000.0 | nM | - |
| CHEMBL375720 | — | IC50 | = | 33100000.0 | nM | - |
| CHEMBL229373 | — | IC50 | = | 102000000.0 | nM | - |
| CHEMBL375518 | — | IC50 | = | 370000.0 | nM | - |
| CHEMBL1453 | DIGITOXIGENIN | IC50 | = | 11800000.0 | nM | - |
| CHEMBL1162954 | — | IC50 | = | 23000000.0 | nM | - |
| CHEMBL229203 | — | IC50 | = | 40900000.0 | nM | - |
| CHEMBL388861 | — | IC50 | = | 16300000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 700000.0 | nM | - |