Assay Detail
Functional
CHEMBL890517
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Antitumor activity against MCF7 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Computer-aided rational drug design: a novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.30 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396281 | — | — | 1 | 7.10 |
| CHEMBL244813 | — | — | 1 | 7.05 |
| CHEMBL395482 | — | — | 1 | 6.96 |
| CHEMBL245030 | SR-13668 | 1.0 | 1 | 6.72 |
| CHEMBL396280 | — | — | 1 | 6.03 |
| CHEMBL242244 | — | — | 1 | 5.76 |
| CHEMBL428214 | — | — | 1 | 5.48 |
| CHEMBL446452 | ARUNDINE | 3.0 | 1 | 5.26 |
| CHEMBL442270 | — | — | 1 | - |
| CHEMBL242245 | — | — | 1 | - |
| CHEMBL397514 | — | — | 1 | - |
| CHEMBL395292 | — | — | 1 | - |
| CHEMBL244393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396281 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL244813 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL395482 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL245030 | SR-13668 | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL396280 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL242244 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL428214 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL446452 | ARUNDINE | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL442270 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL242245 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL397514 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL395292 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL244393 | — | IC50 | > | 10000.0 | nM | - |