Compound Detail
CHEMBL245030
SR-13668 Phase I
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Phase I
Basic Information
| ChEMBL ID | CHEMBL245030 |
| Name | SR-13668 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | BMTPVPNVQOYGAP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
12
Publications
2
Known Names
1
Mechanisms
Molecular Properties
430.5
MW (Da)
5.32
ALogP
5
HBA
2
HBD
93.4
PSA (Ų)
0.37
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Serine/threonine-protein kinase AKT inhibitor | INHIBITOR | RAC-alpha serine/threonine-protein kinase | ✓ | ✓ |
Activity Summary
IC50 1 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MCF7 CHEMBL387 | IC50 | 6.72 | 6.72 | 190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MCF7 | IC50 | = | 190.0 | nM | 6.72 | Antitumor activity against MCF7 cells | 17602463 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17602463 | 10.1021/jm070040e | Unchecked | 4 |
| 17602463 | 10.1021/jm070040e | Rattus norvegicus | 4 |
| 17602463 | 10.1021/jm070040e | Mus musculus | 3 |
| 17602463 | 10.1021/jm070040e | MCF7 | 1 |
| 17602463 | 10.1021/jm070040e | Glycogen synthase kinase-3 beta | 1 |
| 17602463 | 10.1021/jm070040e | RAC-alpha serine/threonine-protein kinase | 1 |
| 17602463 | 10.1021/jm070040e | RAC-gamma serine/threonine-protein kinase | 1 |
| 17602463 | 10.1021/jm070040e | RAC-beta serine/threonine-protein kinase | 1 |
| 17602463 | 10.1021/jm070040e | 3-phosphoinositide-dependent protein kinase 1 | 1 |
| 17602463 | 10.1021/jm070040e | MDA-MB-231 | 1 |
| 17602463 | 10.1021/jm070040e | PC-3 | 1 |
| 17602463 | 10.1021/jm070040e | SK-OV-3 | 1 |
Data from ChEMBL 36 via Core Engine