Assay Detail
Functional
CHEMBL890718
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Agonist activity at mGlu4 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.61 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 6.16 |
| CHEMBL229697 | — | — | 1 | 6.14 |
| CHEMBL227288 | — | — | 1 | 5.73 |
| CHEMBL34880 | — | — | 1 | 4.39 |
| CHEMBL287703 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL229697 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL227288 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL34880 | — | EC50 | = | 40800.0 | nM | 4.39 |
| CHEMBL287703 | — | EC50 | > | 1000000.0 | nM | - |