Compound Detail
CHEMBL227288
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Basic Information
| ChEMBL ID | CHEMBL227288 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RACNCOSUCJNQDH-WUJLRWPWSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
195.1
MW (Da)
-1.03
ALogP
3
HBA
4
HBD
120.8
PSA (Ų)
0.43
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 5.73
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 5.73 | 5.73 | 1850.0 | 1 |
| Metabotropic glutamate receptor 8 CHEMBL3228 | EC50 | 5.67 | 5.67 | 2150.0 | 1 |
| Metabotropic glutamate receptor 6 CHEMBL4573 | EC50 | 5.47 | 5.47 | 3410.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 1850.0 | nM | 5.73 | Agonist activity at mGlu4 receptor expressed in HEK 293 cells assessed as effect... | 17602546 |
| Metabotropic glutamate receptor 8 | EC50 | = | 2150.0 | nM | 5.67 | Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect... | 17602546 |
| Metabotropic glutamate receptor 6 | EC50 | = | 3410.0 | nM | 5.47 | Agonist activity at mGlu6 receptor expressed in HEK 293 cells assessed as effect... | 17602546 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17602546 | 10.1021/jm070262c | Metabotropic glutamate receptor 4 | 2 |
| 17602546 | 10.1021/jm070262c | Metabotropic glutamate receptor 6 | 2 |
| 17602546 | 10.1021/jm070262c | Metabotropic glutamate receptor 8 | 2 |
| 17602546 | 10.1021/jm070262c | Metabotropic glutamate receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine